News Archives - Page 2 of 10 - Washington National Primate Research Center

O’Connor Earns Faculty Appointment

Congratulations to Dr Megan O’Connor on her appointment as Assistant Professor to the Department of Laboratory Medicine and Pathology at the University of Washington!

Megan, a Core Scientist at WaNPRC in the Infectious Disease and Translational Medicine Unit (ITDM) and Research Assistant Professor in the Department of Microbiology at UW, uses preclinical models to study HIV viral co-infections, with a particular emphasis on how in vivo immunosuppression shapes viral pathogenesis, host immunity, the microbiome, and response to vaccination. Ultimately, her goal is to improve treatment and vaccine strategies for people living with HIV and other immunocompromised individuals. Through this research program, she aims to uncover new insights into immune system dynamics and inform the development of more effective therapeutic interventions for a broad range of infectious diseases.

Megan first became interested in academic research during a high school internship at the Oregon National Primate Research Center, under the mentorship of Drs. Steven Kohama and Martha Neuringer. “Having an independent laboratory is something I’ve been working towards since I started research 20 years ago! It’s very exciting!” she said. She is looking forward to growing her scientific program, expanding her collaborations and professional friendships, and is deeply committed to training the next generation of scientists.

She completed her bachelor’s degree from the University of California, Berkeley. She found her passion for studying infectious diseases at the Vaccine and Gene Therapy Institute (VGTI) at Oregon Health and Sciences University. And she received her PhD in Immunology, under the mentorship of Dr. William Green, at the Geisel School of Medicine at Dartmouth, where she studied innate immune mechanisms contributing to LP-BM5 murine retroviral pathogenesis and immunodeficiency. She completed her postdoctoral training in the laboratory of Dr. Deborah Fuller at the University of Washington and evaluated pre-clinical nucleic acid vaccines against HIV, ZIKV, HBV, and SARS-CoV-2.

She enjoys spending quality time with her husband and 2 young daughters, and in her free time you’ll find her cooking, battling it out in board games, or staying active with running and hiking adventures.

She will start her new role on Feb 1.

WaNPRC Highlights at NHP AIDS Conference

The 41^st Annual symposium on Nonhuman Primate Models for AIDS is under way in New Orleans this week, and the Washington National Primate Research center is well-represented by both speakers and attendees.

The WaNPRC contingent consists of session speakers, poster presenters and attendees. “This meeting is the only one of its kind in the world,” said Dr. Kristina Adams Waldorf, Interim Director of Research at WaNPRC. “The symposium includes research presentations on HIV, HIV-like viruses, such as SARS-CoV-2, influenza, Zika, Valley Fever and others that nonhuman primates serve as a close model to human infection that can be used in nonhuman primates to model AIDS, With 38 million people currently estimated to be living with HIV worldwide, the need to develop better treatments and interventions to prevent and/or cure HIV infection remains critical.”

Dr. Chris Peterson, a WaNPRC Affiliate with the Fred Hutch Cancer Center, is presenting on research targeting an HIV-like virus in macaques with (chimeric antigen receptor) CAR-T cells that are specific for a viral protein. “A major challenge to cure HIV is that antiretroviral therapy suppresses the virus to the point that it is essentially invisible to the immune system, but is not curative,” Dr. Peterson said. “What we’re trying to do here is extend how long our CAR T-cells work in the body, so that they more time to locate these rare, infected target cells, leading to a cure.”

Also presenting is Professor Donald Sodora, PhD, Adjunct Professor of Global Health, on the impacts of an HIV-like virus on the liver of nonhuman primates.

WaNPRC was important in establishing the symposium which began as a way for all seven NPRCs to meet and discuss research on the AIDS pandemic using nonhuman primates. At the time, primates were the only animal model that could be infected with a virus that was similar to HIV and develop AIDS symptoms.

“Back then, the NPRCs had been around for about 10-15 years, and were mostly focused on neurosciences,” said WaNPRC Director Dr. Deb Fuller. “But several scientists in infectious diseases at WaNPRC and others at Tulane first showed that old world monkeys (rhesus macaques at Tulane and pigtails at WaNPRC) could be infected with SIV. This launched a huge influx of funding from the NIH into the NPRCs to lead research in NHPs on AIDS and to this date, NIAID is still a major contributor to the P51 and U42 center grants that each NPRC is funded under to support their robust AIDS research programs.”

and has become a meeting place for a large number of scientists and Early-Stage Investigators, many of whom will give their first presentations.

One WaNPRC presenter is Orlando Cervantes, a graduate student in the Adams Waldorf Laboratory. He’ll be sharing his findings on how pandemic influenza infections during the third trimester of pregnancy damage the placenta by provoking a strong immune response.

“Scientists and doctors still don’t fully grasp the ways influenza infection can lead to stillbirth or preterm birth in pregnant women,” said Orlando. “By better understanding the placenta’s response to a maternal influenza infection, we can get clues on how that can compromise placental integrity and hurt the developing fetus. I’m very excited to share these findings because they can encourage other scientists to begin using NHP models to study the interaction between pregnancy and other illnesses/infections.”

The symposium follows on the heels of the HIV Vaccine Trials Network Early Stage Investigator conference, which also took place at the same location. The conference aimed at early-stage investigators (ESIs) specializing in translational HIV research in non-human primates (NHPs) and clinical HIV and TB research is set to offer participants valuable opportunities for professional growth. Attendees will gain insights into their potential contributions to the field and receive support in achieving key career milestones. Previous participants have reported that the event enhanced their skills and knowledge, while also providing a platform for building new collaborations.

Several WaNPRC researchers will have posters at the meeting including Director Deborah Fuller, Associate Director of Research Dr. Kristina Adams Waldorf, and Dr. Charlotte Hotchkiss, D.V.M, Ph.D. As well as the following:

Megan O’Connor – HIV/COVID-19 and/or HIV/ZIKV co-infection
Chris Peterson – HIV
Serena deBanco – HIV (scholarship recipient)
Megan Fredericks – Valley Fever

The symposium concludes October 25.

New Light Helps Reset Your Internal Clock: “Thank a Monkey”

As we move deeper into fall and the hours of daylight dwindle, a trio of researchers from the same family has worked together to create new technology that helps humans improve our health and our moods by managing our circadian rhythms. And they say we can thank research monkeys for it.

In new research from professors Jay and Maureen Neitz of the UW Department of Ophthalmology, and their youngest daughter Alex (who was a graduate research assistant at UW and is now a postdoctoral researcher at the University of California San Diego) helped show that, an LED light that emits alternating wavelengths of orange and blue light helped boost melatonin levels in a group of study participants, shifting their “internal clocks” to align how our body’s supposed to act during different times of day.

The findings, published in the Journal of Biological Rhythms, show that the alternating wavelengths can influence circadian rhythms, an effective approach to counteract seasonal affective disorder (SAD), among other maladies.

A host of health and mood problems are attributed to out-of-sync circadian rhythms, Jay Neitz says. The result is “social jet lag” that occurs during seasonal changes and a lack of exposure to natural light, not to mention night jobs and international travel.

“In extreme cases what this being not synchronized has been linked to diabetes and cancer and all sorts of problems,” he said. “At the very least, people just aren’t at their best. They don’t feel great because their internal clock isn’t set right. Theirs’s huge interest in this kind of thing.”

The Neitzes designed an experiment using light that alternated between short- and long-wavelength components that advanced the circadian phase by an average of almost an hour and a half.

And it’s led to the development of products that produce these alternating blue/orange wavelengths. Called “TUO Circadian Smart Products,” the line consists of an LED lightbulb and various lamps, which can be managed by a smartphone app.

All this from the trio who mesh work and life and always have.

“There’s a lot of talk about work life balance,” said Jay. “Our work and lives have just been one thing. We work all the time, and we have two daughters. Our younger daughter, Alex, started working in our lab as a child.”

“It wasn’t like this started in grad school it was a gradual process,” Alex said. “In grad school I was interested in circadian rhythms, and I went to grad school immediately after undergrad.”

Like mother, like daughter. Maureen and Alex are both molecular biologists who wound up interested in studying vision and the nonhuman primate model.

Jay credits NHP research stemming from a grant that helped Maureen obtain an electron microscope that enabled researchers to build a complete look at the retina that was the foundation for research that led to the Tho light. So none of it would have happened without NHP research.

“There are things about the way our eyes work and how they communicate with the central parts of our brain that are unique to primates,” Jay said, recalling contributions of WaNPRC’s Tissue Distribution Program. “Because of that we got preservation of microdetails of all cells in the retina that could never be gotten from a human. We believe what we’re seeing in the NHP model is exactly like what happens in a human. There’s just no other example like this.”

Increased Support for NHP Neuroscience Research “Critical” to Advance Human Health

Increasing investment and support for neuroscience research involving monkeys is critical to realize our hope for advancing human health and reducing suffering for millions of people confronting diseases like Alzheimer’s, bipolar dis- order, depression, anxiety, schizophrenia. So argues Dr. Michele A. Basso, core scientist in the Neuroscience unit of the Washington National Primate Center.

Portrait of Dr Basso — Dr Michele A. Basso is a core scientist in the Neuroscience Unit of WaNPRC

Basso and partners with the Simian Collective penned an urgent commentary in the Journal of Neuroscience this month, framing the nonhuman primate neuroscience as one of “peril or possibilities.”

In the piece, Basso notes that the cost to the United State to treat neurological and neuropsychiatric disorders at more than $1 trillion annually. And that monkeys will be necessary for the discovery, development, and testing of treatments because monkeys share traits with humans that other testing animals lack.

A big hurdle to progress is a shortage of monkeys for research, highlighted in a 2023 report from the National Academy of Sciences, Engineering, and Medicine. The shortage, and subsequent high costs, prevents scientists from advancing treatments.

“To ensure a sustainable resource of non- human primates for biomedical research, including and especially in neuroscience, the US must engage in domestic capacity building,” Basso argues.

And while new approach methods are pursued, she writes, “developing treatments and cures for Alzheimer’s disease and related neurodegenerative diseases, and the many neuropsychiatric illnesses, will all ultimately require an understanding of the brains of primates and perhaps the immune system, which, like the brain, is significantly more like humans in monkeys than in rodents.”

Read the full text in the Journal of Neuroscience. Explore the Neuroscience unit at WaNPRC.

Neuroscience Unit’s New Discoveries: Unraveling the Mysteries of the Brain

WaNPRC’s Neuroscience unit has contributed four noteworthy advances in science in recent months, including a new discovery about color vision, advancements in how primate brains differentiate objects, and even how our brains help us chew and swallow food.

New findings from the lab of Core Scientist Dennis Dacey, PhD, are unraveling the complex circuitry of the human retina, where vision starts. His lab’s results suggest new pathways for color vision and emphasize the need for complete wiring diagrams of the human central nervous system.

Dacey mapped, cell-by-cell, the physical pathway that color signals travel through the retina. Before Dacey’s discovery, it was thought there were two color pathways: a red/green path, and a blue/yellow path. Dacey found that some cells carry both at same time.

“They’re re-writing the book on the retina,” said unit chief Greg Horwitz, PhD, praising Dacey, who is the most senior member of the unit. “The part of the retina that Dennis is focused on is the part that resolves fine details. And it’s the part that fails in macular degeneration. It is usually thought of as a high-resolution version of the rest of the retina, but Dennis’s work is showing it’s actually highly specialized.”

Horwitz himself also recently published a paper with Research Associate Professor Robi Soetedjo, PhD, announcing new findings about how specific cells in the brain control certain eye movements known as saccades

Horwitz and Soetedjo used a laser to stimulate Purkinje cells in the cerebellum of a monkey at the precise moment of saccade. They found that if the monkey looked in one direction, the saccade slowed. If the monkey looked the other direction, saccade went beyond the expected target, showing that they are not just two opposing functions

“It gives us a tool. If it works in eye movements, it might work for studying other cerebellar functions including movements of the arms or body,’ Horwitz said

Their findings were published in the Journal of Neuroscience in February.

Four months later, Anitha Pasupathy, PhD, and her ShapeLAB team published a paper in the same journal, advancing our understanding of how neurons in a primate’s brain process objects that are part of a group.

Pasupathy’s lab showed primates a target image – let’s say a yellow triangle – and compared how neurons in the brain’s visual cortex responded when the triangle was surrounded by similar versus dissimilar objects. From these measurements, they discovered that the brain could differentiate the target object more readily when it stood out from the dissimilar objects.

“What that tells us is the brain has a way of suppressing activity of things that are similar,” Pasupathy said. “For efficiency, the brain may pool similar objects and encode them together. But that center yellow triangle is special when it’s surrounded by dissimilar objects, and maybe it’s something of interest to the visual system.”

She said the next step will be tests to see if monkeys can pick out objects they see, and whether that corresponds to what neurons are telling the researchers.

Fritzie Arce-McShane, PhD, published a paper in Nature Communications (and recent pre-preprints here and one on age-related changes here) furthering our understanding of how the brain drives the muscles involved in chewing and swallowing in ways that could lead to new interventions that could help patients having trouble with these vital functions due to aging or brain disease, such as Alzheimer’s Disease.

“How the brain controls chewing and swallowing is very much understudied and the big challenge in studying this is tracking the position and shape of the tongue inside the mouth when we chew and swallow,” Arce-McShane said.

Using a combination of x-ray technology with sensors and machine learning-based analyses of brain signals, her studies have shown that when primates eat, there is robust information in the primary motor cortex and the somatosensory cortex that define the 3D direction of tongue movements, and also the tongue shape. “That hasn’t been shown before. The tongue’s shape has importance in positioning the food and preparing it for swallowing,” she said. Changes in the pattern of tongue movements have been observed with aging and Arce-McShane expects that these changes will also be reflected in the brain signals.

The Neuroscience unit at WaNPRC is dedicated to supporting state-of-the-art research in nonhuman primates both inside and outside the WaNPRC. Nonhuman primates have and continue to play a critical role in advancing our understanding of how the human brain works due to their close similarities in structure, physiology, and genetics to humans. Using nonhuman primates, the Neuroscience Unit at WaNPRC is at the cutting edge of advancing our understanding of the function of the human brain and developing new treatments for a wide range of neurological disfunctions. You can find more information on the Neurosciences Unit and the exciting research of its 23 core and affiliate faculty here.

Personal Legacy Meets Medical Breakthrough: WaNPRC Research Offers Hope for Heart Disease Patients

WaNPRC researchers have made a promising discovery in the fight against heart disease. Cardiologist and researcher Dr. Chuck Murry of WaNPRC’s Gene Therapy and Regenerative Medicine unit is leading an effort using special cells called heart muscle cardiomyocytes to address cardiac muscle damage.

Photo of Charles Murry, MD, PhD — Photo/Gavin Sisk, University of Washington

Dr Murry’s team has made a significant breakthrough in collaboration with Sana Biotechnology. They successfully changed induced pluripotent stem cell cardiomyocytes (iPSC-CM) in the lab and transplanted or “grafted” them into two rhesus monkeys with heart damage. These new cells survived and started integrating with the heart muscle cells responsible for contracting and pumping blood. This is a big deal because it means the body did not reject the new cells, which is a frequent problem with transplants.

This pursuit has been a personal one for Murry. His mother, Donna, passed away in 2014 after suffering multiple heart attacks. “She is the kind of person we would like to have helped,” he told the Seattle Times in 2014.

Another challenge with using these new heart cells is that they sometimes cause irregular heartbeats. The team has also found a way to fix this problem by making changes to the genetic makeup of the cells. Noninvasive PET imaging has shown that the transplanted iPSC-CMs remained stable and functional in the heart for periods of 6 and 12 months without suppressing the immune system. This persistence without rejection indicates that the cells integrated well with the heart tissue and continued to perform their intended functions over these extended periods.

These findings mark a significant step forward in the treatment of heart disease and bring hope to millions of patients. While human trials are still to come, this research lays the groundwork for a future where damaged hearts can be effectively repaired.

Dr Murry recently began his appointment as head of USC’s Department of Stem Cell Biology and Regenerative Medicine.

First Authors: Yongshun Lin Noriko Sato, Sogun Hong, and Kenta Nakamura. Senior Authors: Charles Murry (pictured), Manfred Boehm, and Cynthia Dunbar. 

Cell Stem Cell | DOI: https://pubmed.ncbi.nlm.nih.gov/38843830/

WaNPRC’s Orsborn Adds NSF CAREER Award to Study Neural Interfaces

Amy Orsborn, Neuro core scientist at WaNPRC and Clare Boothe Luce Assistant Professor in Electrical & Computer Engineering and Bioengineering at the UW, was recently named a recipient of the prestigious National Science Foundation (NSF) CAREER award. The award will support Orsborn’s research investigating how the brain and nervous system respond to using sensorimotor neural interfaces, which show promise for treating a wide range of neurological conditions, such as paralysis caused by spinal cord injury or stroke.

Orsborn’s work will help to lay a foundation for creating advanced computer algorithms in sensorimotor neural interfaces that can better adapt to the user. Her research is inspired by a fundamental challenge in neural engineering, where neural interfaces engage with the brain and nervous system in what is called a “closed loop” in which the user and the device influence each other. This closed loop has enormous therapeutic potential. Her aoLab will conduct experiments using two different types of neural interfaces: muscle/nervous system interfaces applied to humans on the surface of the skin, and brain-computer interfaces applied to the sensorimotor cortex of non-human primates. Comparing the results could help the team understand how the brain performs computations and how closed loop devices influence them.

The NSF selects award recipients who are faculty members at the beginning of their careers to lead advances in the mission of their department or organization. The intent of the NSF CAREER program is to provide stable support, enabling awardees to develop not only as outstanding researchers but also as educators demonstrating commitment to teaching, learning and dissemination of knowledge.

Orsborn has been racking up accolades. She recently received the Ronald S. Howell distinguished faculty fellowship. The Electrical & Computer Engineering department has more on the story.

Exciting Collaborations

Ongoing studies with Umoja Biopharma, HDT Bio, and the Allen Institute

Nonhuman primate studies are crucial in biomedical research, particularly developing new therapies. The pigtail macaque monkeys at the Washington National Primate Research Center share a closer genetic and physiological resemblance to humans than other animal models. This similarity allows researchers to predict better how a therapy might behave in humans, offering valuable insights into potential efficacy and safety.

Such is the case with Umoja Biopharma’s VivoVec platform for chimeric antigen receptor T (CAR-T) cell therapy. In this in vivo study, the researchers observed the activation and expansion of CAR-T cells in the monkeys and their impact on target cells. The researchers, supported by the animal care and research staff at WaNPRC, compared the CAR-T cell expansion and persistence in monkeys with data from previous studies on ex vivo CAR-T therapies in similar primate models. This provided valuable insights into the platform’s potential advantages.

Overall, this public/private partnership is a critical bridge between preclinical research and clinical translation, providing essential data on the safety, efficacy, and feasibility of new therapies like Umoja’s VivoVec platform for CAR-T cell therapy.

A separate project led by HDT Bio Formulations Director, Dr. Amit Khandar, aims to assess the effectiveness of their LION™ delivery technology and self-replicating RNA (repRNA) vaccine platform against HIV-1. The focus is on inducing broadly neutralizing antibodies (bNAbs), crucial for targeting the heavily masked envelope glycoprotein of the virus. In the R33 phase, the collaboration with UW’s Fuller Laboratory and the WaNPRC will evaluate immunogenicity and efficacy in nonhuman primates (NHPs), pivotal steps before potential clinical trials. This phase will provide essential data on protection against a SHIV challenge and guide decisions regarding human trials. Safety assessments, especially concerning mRNA-based vaccines, are emphasized, drawing from mouse models and NHPs to address concerns ensuring confidence in the vaccine’s safety profile. The ultimate goal is to advance toward clinical trials, leveraging promising results from NHP studies to inform future steps in vaccine development.

“Ultimately, it might be that a combination of nucleic acid platforms will be needed to achieve the “holy grail” that is efficacy in humans. The combination of safety, immunogenicity, and efficacy in nonhuman primates will support the decision to enter clinical trials. If the data is promising, we have the manufacturing infrastructure to work with existing HIV clinical trial networks and enter phase I evaluation. – Dr. Amit Khandhar, HDT Bio

Scientists at the Allen Institute celebrate their global collaboration in mapping the hundreds of billions of cells in rodents, macaque monkeys, and human brains. They are mapping them by their type and function as part of the BRAIN Initiative® Cell Atlas Network, or BICAN, with financial support from NIH’s B.R.A.I.N. Initiative, or Brain Research Through Advancing Innovative Neurotechnologies® Initiative.

The WaNPRC, by providing the Allen Institute’s NHP models, is helping to bridge the knowledge gap between rodent models and humans.

“The Allen Institute has made amazing progress characterizing the cell types that compose the mouse brain and connections among them. Extending these efforts to primates is a critical next step on the way to clinical application. This is being achieved via the symbiotic relationship they have with the WaNPRC.” – Dr. Gregory Horwitz, WaNPRC Neuroscience unit chief

This brain atlas lays the groundwork for mapping the entire mammalian brain and enhancing comprehension of puzzling brain disorders, such as those affecting the neurons responsible for motor function, like amyotrophic lateral sclerosis (ALS).

Highlights from the Himalayas

Dr Randy Kyes, chief of the Global Conservation, Education & Outreach unit at the WaNPRC, and his Nepali colleagues wrapped up their 21st year of field training in Kathmandu, Nepal, before gaining some altitude in their annual climb up to their field sites in Langtang National Park. This was a return the site of a devastating 7.8 magnitude earthquake and resulting landslide in April of 2015.

Kyes and his Nepali colleagues highlighted their dedication and collaboration over the past two decades in a two-day photo exhibit titled “Langtang Through the Lens of Field Researchers.” The event was hosted at the Central Library of Tribhuvan University (TU) and sponsored jointly by the library itself, and the university’s Department of Library and Information Science, along with the Central Department of Zoology.

The exhibition provided a visual journey into the heart of the Himalayas and served as a celebration of over two decades of partnership and collaborative research, training, and outreach in the Langtang region.

At the heart of this celebration were the tireless efforts of dedicated field researchers, including long-time collaborators like Prof. Mukesh Chalise and past students turned colleagues, Dr. Narayan Koju and Dr. Laxman Khanal. In a moving speech at the opening of the event, Kyes also expressed his gratitude to the local residents of Langtang for their years of support noting that this exhibition is dedicated to their dear friends who were lost in the terrible 2015 earthquake and landslide.

Supported in part by OEI, USA, the exhibition not only showcased the beauty of Langtang, but also underscored the importance of these photographs as valuable sources of information for future research endeavors. It served as a reminder of the enduring impact of collaborative efforts in preserving and understanding our natural world.

Collaborating faculty wearing Nepalese khata ceremonial scarves, from left to right: Professor Laxman Khanal, Professor Mukesh Chalise, Professor Randy Kyes, Assistant Professor Narayan Koju — L to R: Associate Professor Laxman Khanal and Professor Mukesh Chalise (Tribhuvan University), Professor Randy Kyes (University of Washington), Assistant Professor Narayan Koju (Nepal Engineering College, Pokhara University)

This collaboration started in 2000 when I first visited Nepal and met with Mukesh Chalise, who became my long-time colleague. Two of our past field course students now colleagues, Laxman Khanal and Narayan Koju, are continuing this long collaboration – leading the way into the future.

Randall C. Kyes, PhDGlobal Conservation, Education & Outreach unit chief

Updates from the Field: Southeast Asia

Friday, February 2, 2024:

Midway through a thrilling three-week macaque distribution survey in Sumatra, spearheaded by Dr. Entang Iskandar from the Primate Research Center (PSSP) at IPB Bogor University, Randy’s journey took an exciting turn. Navigating through the verdant landscapes of the Aceh province, they stumbled upon two substantial groups of macaques, featuring both pig-tailed macaques (Mn) and long-tailed macaques (Mf), congregating along the roadside.

“It has been a pleasure to assist my long-time colleague Dr. Entang Iskandar (Project Leader) with this collaborative effort between PSSP-IPB and WaNPRC.” -Dr. Randy Kyes

A spectacle unfolded before them as they keenly observed instances of interspecific grooming and an unusual closeness between members of both species. The dynamic interaction between the macaque species provided valuable insights into their social behaviors, adding depth to the understanding of their intricate relationships. Photo: Randall C. Kyes

It is a real pleasure to be assisting my long-time colleague Dr. Entang Iskandar who is leading this important study. I’ve worked closely with Entang and PSSP-IPB for over 30 consecutive years and I believe this project represents truly foundational work – helping to fill in the gaps regarding macaque distribution and target locations for in-depth population surveys.
Dr. Randy KyesGlobal Conservation, Education and Outreach unit chief

Saturday, January 27, 2024:

On the fifth day of their collaborative three-week distribution survey in Sumatra, Dr. Entang Iskandar and Randy continued north as they delved into the northern half of the island for Phase 2. Their expedition led them to Taman Kera, Sumatra Utara, where they encountered sizable Mn and Mf macaque groups.

Capturing a defining moment, Randy’s lens focused on an adult male pigtailed macaque. The collective efforts of experts from IPB’s Primate Research Center and WaNPRC’s Global Conservation and Educational Outreach (GCEO) unit continue to unravel the mysteries of macaque distribution and behavior, highlighting the importance of collaborative research in conservation. Photo: Randall C. Kyes

Wednesday, January 24, 2024:

Dr. Kyes expresses his pleasure at returning to Indonesia, once again joining forces with Dr. Entang Iskandar for the second phase of their macaque distribution survey. The collaborative spirit is resonating as they work towards unraveling the nuances of macaque populations of pig-tailed and long-tailed macaques in Sumatra.

Long-tailed macaque sits in tree — A highlight of their venture is an encounter with an adult male long-tailed macaque, captured in a moment of grace. The collective efforts and camaraderie between research partners contribute significantly to their shared goal of understanding and conserving the biodiversity of Sumatra. Photo: Randall C. Kyes

Monday, December 25, 2023:

Baby rhesus monkey on tree branch — As the curtain falls on the 2023 field season at Wat Phrabuddhabat Pa Reau in Chiang Rai, Thailand, a heartwarming scene unfolds – an infant rhesus macaque preparing for a daring leap. This memorable moment serves as a fitting conclusion to a season of discoveries and underscores our commitment to exploring human-primate conflict and coexistence. Photo: Randall C. Kyes

Looking forward to 2024, Randy and research scientist Dr. Pensri (“Elle”) Kyes, along with partners at Mahasarakham University and Mae Fah Luang University promise to delve deeper into the intricate dynamics of the relationship between humans and wild monkeys. The journey continues, and their shared dedication to bridging the gap between humans and primates propels them into the new year with enthusiasm and determination.