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High Throughput and Molecular Profiling Core (HTMPC)

The HTMPC is an incubator for technology development and for devising and conducting functional genomics/transcriptional profiling methods to study NHP models and systems biology. The HTMPC has established robust bulk RNAseq and scRNAseq pipelines supported by full instrumentation, and also provides specialty analyses of ChipSeq, ATACSeq, and other applications for functional genomics to support NHP studies. The HTMPC will provide high throughput genome-wide assays to support the characterization of the NHP models described in this application.

The HTMPC develops and provides genome-wide data generation pipelines for molecular profiling of infectious disease models for the Division and the NHP research community. This expertise can be accessed by external investigators through the WaNPRC genomics core, Seattle Genomics.

Key capabilities include:

  • Single cell RNA sequencing
  • Bulk RNAseq, including mRNAseq and Total RNAseq assays
  • NanoString cCounter data generation
  • Future capabilities that are in development include pan-virus discovery, CITEseq, ATAC-seq, and spatial transcriptomics methodologies to profile gene expression in the context of the tissue microenvironment