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Researcher Wins SPARK Competition Prize ‘Reimagining’ Chemistry Set

Prototype Toy Allows Kids to See Effects of Body’s Electrical Signals

SPARK Competition prize awarded to Robijanto Soetedjo, MD, PhD,  for prototype toy allowing kids to explore electrical signals from the human body. Dr. Soetedjo created platform while trying to explain his research to his own children — Dr. Soetedjo is a neuroscientist with the University of Washington and Washington National Primate Research Center. The Gordon and Betty Moore SPARK-1Foundation and Society for Science & the Public awarded Dr. Soetedjo a second place prize worth $25,000 for their Science, Play and Research Kit (SPARK) challenge to reinvent a chemistry set for the 21st century.

Dr. Soetedjo developed a toy set that children can experiment with to see the effects of the electrical signals produced by their muscles, their hearts, and even their brains. Electrodes are attached to a part of the body, such as the forearm, and to another device that shows them the effects of their electrical signals. For example, by tightening a hand grip, the child can turn on a light, spin a propeller, control a motor or (through an audio amplifier) emit a sound. The toy set can also interface with a range of computer devices and helps opens up the space of neuroscience and biofeedback as areas for children to explore in play.

SPARK Competition

The SPARK Competition focused on science beyond chemistry, challenging the nation’s most creative minds to develop projects and ideas that will encourage imagination and interest in science and technology, inspiring today’s children – often through immersive play and learning through doing. Many of today’s scientific SPARK-2innovators – including Moore Foundation and Intel co-founder Gordon Moore – attribute their early fascination with science to their childhood chemistry sets. Yet, the chemicals in these classic sets are now illegal and replacement sets often lack elements of excitement and wonder. The competition sought to elicit new catalysts that could foster the persistent curiosity and creativity that lead to longer term engagement in science and engineering, as well as to put a spotlight on the importance of experiences that ensue from unscripted exploration and tinkering.

“As a whole, these [SPARK] winners conveyed an exciting variety of ways to get kids hooked on science and engineering,” said Paul Gray, PhD, interim president of the Moore Foundation.

One hundred twenty-five entries were received in the competition, which awarded a total of $136,000 in prize money. Sixteen projects were selected for recognition. View a full list of the winners. Entries went through several rounds of judging by groups of independent evaluators selected for their scientific, engineering or education expertise.

Read more about Dr. Soetedjo’s award-winning home invention in an article from the Seattle Times published April 9, 2014.

 

This is a personal project for Dr. Soetedjo and no state-funded time was
spent working on this personal endeavor.

PBS Films at WaNPRC

Three-part series, “Your Inner Fish” films at Washington National Primate Research Center. The show traces more than 350 million years of human evolution to show how human bodies have taken shape. PBS show is based on a book by paleobiologist Neil Shubin, who also hosts the series.

Your Inner Fish

Your Inner Fish is a scientific adventure that takes viewers from Ethiopia to the Arctic Circle on a hunt for the many ways that animal ancestors shaped our anatomical destiny. Shubin has spent much of his life searching for the deep pedigree of Homo sapiens. Using both the fossil record and DNA evidence, he traces various parts of our body’s structure to creatures that lived long, long ago. Along the way, he makes it clear that we can thank our fishy origins for many human characteristics.

The final episode in the series, “Your Inner Monkey,” was filmed in part at the Washington National Primate Research Center’s Infant Primate Research Laboratory. While at our facilities the crew captured the outstanding research of Drs. Tom Burbacher, Kim Grant, Jay Neitz and Maureen Neitz.

PBS Films at WaNPRC

During this episode, Shubin delves into our primate past. He travels from the badlands of Ethiopia, where the famous hominid skeletons “Lucy” and “Ardi” were found, to a forest canopy in Florida, home to modern primates. En route, he explains how many aspects of our form and function evolved. We learn that a genetic mutation in our primate ancestors conferred humans’ ability to see in color — but it was an advantage that led to a decline in our sense of smell. The shape of our hands came from tree-dwelling ancestors for whom long fingers made it easier to reach fruit at the tips of fine branches. Shubin concludes by tracing the evolution of the human brain — from a tiny swelling on the nerve cord of a wormlike creature, to the three-part architecture of a shark’s brain and the complex brain of primates. As Shubin observes, “Inside every organ, gene and cell in our body lie deep connections with the rest of life on our planet.”

Visit www.pbs.org/your-inner-fish to find air dates of this PBS series in your area. The site also includes classroom materials for further discussion.

Researchers hope to protect against HIV-like outbreak

By Bobbi Nodell and Kristen Woodward
UW Health Sciences | UW Medicine  Fred Hutchinson Cancer Research Center

Researcher of HIV-like outbreak says Asian rhesus macaques to continue to thrive in human-altered habitats
Asian rhesus macaques, unlike many other species of primates, are going to continue to thrive in human-altered habitats, according to UW researcher Lisa Jones-Engel. Photo: Lynn Johnson

Throughout Asia, humans and monkeys live side-by-side in many urban areas. An international research team from the University of Washington, Fred Hutchinson Cancer Research Center and Jahangirnagar University has been examining transmission of a virus from monkeys to humans in Bangladesh, one of the world’s most densely populated countries.

The scientists have found that some people in these urban areas are concurrently infected with multiple strains of simian foamy virus, including recombinant strains — those from more than one source — originally detected in the monkeys.

“These Asian rhesus macaques are Darwinian superstars,” said Lisa Jones-Engel, a primatologist with the Washington National Primate Research Center and the project leader. “They are very responsive to change and, unlike many other species of primates, they are going to continue to thrive in human-altered habitats.”

Could Simian Foamy Virus be Next HIV-Like Outbreak?

Simian foamy viruses, which are ubiquitous in nonhuman primates, are retroviruses that exhibit high levels of mutation and recombination – a potentially explosive combination.

In a paper published Sept. 4 in the journal Emerging Microbes & Infections, the scientists characterize the simian retroviral strains that are being transmitted between species and provide a glimpse into the behaviors of humans and monkeys contributing to the infections.

By analyzing what is happening at the human-primate interface, the researchers hope to protect humans from another deadly outbreak similar to HIV.  They focus on Asia because that continent has witnessed the emergence of several infectious diseases in the past decade. Asia also has a volatile combination of a population that is increasingly mobile and with a compromised immune response living in proximity with animals.
A man with a performing monkey.

In the study, researchers collected biological samples from a group of nomadic people who travel throughout Bangladesh with their performing monkeys. The research team found that transmission of simian foamy virus between species occurred most commonly through bites.

In the study, researchers collected biological samples from hundreds of people and macaques in five urban sites, as well as from a group of nomadic people who travel throughout Bangladesh with their performing monkeys.

Read the full article from UW Today.

Fulbright Specialist Grant Awarded to Randall Kyes

WaNPC Fullbright Scholar Award

WaNPRC Scientist Receives Fullbright Specialist Grant

Dr. Randall Kyes awarded with Fullbright Specialist grant. Kyes is a Core Scientist at the WaNPRC and Research Professor in Psychology and Adjunct in Global Health is the Director of the Center for Global Field Study with the University of Washington. Kyes will travel to Indonesia at the end of June for a one-month program that involves giving lectures and conducting short training programs focusing on “conservation biology & global health – at the human-environment interface.” During the program, Kyes will work with colleagues at the Univ. of Indonesia in Java; Hasanuddin Univ. and Tadulako Univ. in Sulawesi; and Andalas Univ. in Sumatra. This award extends the collaborative partnerships that were established during a special Fulbright recharging program conducted by the Univ. of Washington in the Fall of 2012 that involved hosting 14 senior scholars from Indonesia.

PBS Documentary Crew at WaNPRC

PBS films at Primate Center
PBS host, Neil Shubin, holds an infant macaque after learning proper handling procedure. The toys in the foreground were used in object permanence testing.

PBS/BBC-based TV production company and evolutionary biologist, Dr. Neil Shubin film at Washington National Primate Research Center. The crew captured the outstanding research of Drs. Tom Burbacher, Kim Grant, Jay Neitz and Maureen Neitz.

Primate Center researchers, research technicians and animal care staff worked with Center Programs and UW Medicine Strategic Marketing & Communications personnel to accommodate the filming while maintaining normal operations.

Although we won’t see the resulting documentary for some time, the Primate Center received laudatory feedback from the author, producer and film crew.

WaNPRC Researcher Finds Critically Endangered Monkey Population Shifts to Sustainability

Kyes-AJP-CoverPhoto1-MnigraAmerican Journal of Primatology (AJP) published article by Dr. Randy Kyes, Core Staff Scientist with the Washington National Primate Research Center, on the stabilization of critically endangered Sulawesi black macaques. The findings support a shift in population sustainability of the Macaca nigra living in an Indonesian nature reserve after decades of decline.

Read the full article published in the January 2013 issue of AJP. Overview information about the article is available from University of Washington News and Information and The Daily.

Center scientists conduct field course for students at Quileute Tribal School

Dr. Randy Kyes, head of the WaNPRC’s Division of Global Programs, and colleague Dr. Pensri Kyes offered a three-day, mini-field course titled “College Prep-Field Course in Conservation Biology & Global Health: At the Human-Environment Interface” for 18 middle and high school students from June 4 to June 6 at the Quileute Tribal School in La Push, Washington.

The course, modeled after current UW-level field courses, consisted of daily lectures and related field and lab exercises. Lecture material was presented at an advanced (college-prep) level to give the students a feel for what college-level lectures are like.

“By exposing the students to college-level material, we hope dispel any myths about what a college course is like and in turn give them the confidence to pursue post-secondary education in the sciences,” Kyes said.

Topics included an introduction to conservation biology and global health, field study methods, management and conservation strategies, primate behavior and ecology, the human-wildlife interface, issues in global health, and animal research and translational science.

Based on the success of this first college-prep field course, Kyes plans to expand this outreach education program to other tribal schools in the area.

“We received wonderful feedback from the students and teachers at the Quiluete Tribal School who asked us to make this an annual program at their school and to provide this field course for other tribal schools such as the Makah Tribal School in Neah Bay,” Kyes said.

In addition to heading the WaNPRC’s Division of Global Programs, Kyes is also Director of the Center for Global Field Study. For 22 years, in partnership with his international colleagues, Kyes has conducted annual field courses in the areas of primatology and conservation biology for university students and professionals in a number of countries including Indonesia, Nepal, China, Bangladesh, Democratic Republic of Condo, Thailand, and Mexico.

NPRCs help celebrate science at USA Science and Engineering Festival

1204usa_science
Diana Gordon, education outreach specialist for the Oregon National Primate Research Center, explains the effects of second-hand smoke to a student at the USA Science Engineering Festival from April 27 to April 29 in Washington D.C.

Representatives from the National Primate Research Centers (NPRCs) spoke to an estimated 4,000 people who visited the NPRC booth at the 2nd annual USA Science and Engineering Festival from April 27 to April 29 in Washington D.C.

Billed as “the largest celebration of science in the U.S.,” the festival featured more than 3,000 interactive exhibits, more than 100 stage shows and 33 author presentations. More than 150,000 people attended. President Barack Obama attended a special event at the festival on April 27 to promote STEM (science, technology, engineering and mathematics).

The NPRC booth included a flip board with answers to common questions about animal research and a set of pig lungs (healthy and “smoker’s”) to demonstrate the effects of second-hand smoke on lung development. The booth also supplied NPRC bookmarks and information on all eight NPRCs.

The booth was staffed by: Kathy West and Keidri Herring, California National Primate Research Center (CNPRC); Diana Gordon and Steve Gordon (spouse), Oregon National Primate Research Center (ONPRC) ; and Jordana Lenon, Wisconson National Primate Research Center (WNPRC).  Other NPRCs including the Washington National Primate Research Center (WaNPRC) helped organize the booth as part of the NPRC Consortium Outreach Working Group.

We had many positive comments and interested visitors, and a number of people specifically thanked us for the NPRCs’ research efforts,” West said.

Special visitors to the festival included: The Myth Busters; Arne Duncan Secretary of Education; Bill Nye, the science guy; best-selling authors; astronauts; Nobel Prize-winner Carol Greider; and a rock guitar performance by Dr. Francis Collins, NIH director.

Center hosts ‘Animals and the Future’ exhibit at UW’s PAWS-on-Science activities

1204_kyes_paws_on

The Center’s Division of Global Programs hosted an exhibit titled “Animals and the Future” at the UW’s “PAWS-on-Science” outreach activities from March 30 to April 1 at the Pacific Science Center in Seattle.

The exhibit included information for children on methods used to study animals in the wild and included hands-on activities with some of the equipment and techniques used by researchers in the field. Children had opportunities to learn about radio telemetry, GPS, trap cameras, and biological sample collection.

“The exhibit demonstrated the close relationship between humans and the environment and how animals can provide the first indication of future environmental impact and global health issues,” said Randy Kyes, head of the division and WaNPRC core staff scientist.

“One of the exhibit activities that was a real hit involved a hands-on demonstration of primate fecal sample collection to look for intestinal parasites,” Kyes said. “Of course no real fecal samples were used, but the fake ‘pooh’ attracted a lot of interest.”

Close to 10,000 people attended the three-day outreach event which showcased almost 50 UW research groups.

Deadline to apply for ITHS/WaNPRC Ignition Award is Feb. 17

The Institute of Translational Health Science (ITHS) and the Washington National Primate Research Center (WaNPRC) are pleased to sponsor an Ignition Award, focusing on the use of nonhuman primate models of human disease. The purpose of this Ignition Award is to explore innovative areas of nonhuman primate research and generate preliminary data to serve as a basis for submission of new research grant applications (e.g. R01-type grant to NIH or other funding agency) and/or subsequent clinical studies.  Please pay close attention to the submission instructions and due dates, as there are several important differences from the standard ITHS opportunities.

Key Dates:

  • Feb 17, 2012 – Full application due to the WaNPRC
  • April 2, 2012 – Notice to awardees and other applicants
  • May 1, 2012 – Budget initiation

All faculty members or those with equivalent titles are eligible to apply.
Note:  All applicants must join ITHS prior to submitting an application.

The WaNPRC intends to award one or two separate awards of up to $75,000 for one year.  These funds must be used for Primate Center costs only, including animal costs, per diem, and procedures.  Costs of supplies and salaries must be administered by the Primate Center.

Purpose

This program is designed to support innovative studies utilizing resources within the WaNPRC. Nonhuman primates are the preeminent animal model of the human condition. This award program will facilitate use of NHP models and services of the WaNPRC and resources within the ITHS to provide information applicable to subsequent grant and/or clinical studies. This program will advance research programs through the translational process of therapeutics, diagnostics or device development.

Examples of types of projects include, but are not limited to:

1.   The development of clinical tests/diagnostics/therapeutics that have the potential to

a.    speed translational research (i.e., new outcome measures)

b.    develop highly relevant model systems

c.    improve clinical treatments (i.e., new therapeutics or new indications for approved drugs)

2.   Advanced neuroscience applications

3.   Reproductive / developmental studies

Eligibility and review criteria

All faculty members (or those with equivalent titles) are eligible to apply, except those who have received an ITHS/Primate Center Ignition Award within the previous three years.

Applicants are encouraged to contact the WaNPRC [Ann Schmidt (Research Liasion) or Pat Jobe (Pre-Award Aide)] at: PrimateITHS@wanprc.org to discuss the scientific components of their projects and general costs of the services to be provided.  Complete budgets are required for the Full Applications and must be developed in collaboration with the WaNPRC. The budgets for the NHP studies may only be used for costs within the WaNPRC.

  1. It is the PI’s responsibility to clearly demonstrate how the proposed research has the potential to positively impact the quality or the conduct of clinical and translational research.
  2. The PI should clearly describe how the proposed evaluation methodology provides an innovative approach to conducting the proposed research.
  3. Up to $75,000 per selected applicant will be directly applied to the costs at the WaNPRC.
  4. No additional funds will be provided for indirect costs.  The budgets associated with these awards will be administered by the WaNPRC.

Anyone in the WWAMI region is eligible to apply, provided that all costs are incurred at the Primate Center.

Review committee

The combined Research Review Committee (RRC) for the Ignition Award applications will consist of members of the WaNPRC, and the ITHS Drug and Device Advisory Committee (DDAC).  Members of the committee are selected to provide interdisciplinary insight into the proposed research.  The committee is composed of core and affiliate scientists.  If potential conflict of interest exists, ad hoc members will be appointed.

As needed, the WaNPRC will also invite representation from the Technology Transfer Office of the applicants’ institution for guidance on innovation represented by the technology.

Note: In order to expedite the review and award of the NHP Ignition awards, the WaNPRC has instituted an accelerated review process for this announcement.  There is only one review step – the fullapplication.  No pre-application process is involved.

Full applications will be critiqued and scored by the RRC. It is anticipated that the projects with the lowest score/highest priority will be funded. Based on funding levels, it is anticipated that two or three projects will be funded during this 2012 review cycle.
Reviews are performed according to the following standards:

  1. Applicability to the WaNPRC and ITHS missions
  2. Scientific merit
  3. Proposed activities conducted on site at the WaNPRC
  4. Innovation
  5. Potential impact on human health
  6. Probability of future grant funding and/or clinical studies

Application form and process

Key Dates:

Feb 17, 2012 – Full application due to the WaNPRC

April 2, 2012 – Notice to awardees and other applicants

May 1, 2012 – Budget initiation

Step 1 – Submit the full application to WaNPRC by February 17, 2012 (PrimateITHS@wanpr.org).

Step 2 – Review of Applications

Reviews are performed utilizing the standards described above

Applicants will be notified of their status by April 2, 2012.

Investigators are offered assistance with their applications and budgets by WaNPRC staff, including Ann Schmidt and Pat Jobe.  They can be contacted via PrimateITHS@wanprc.org

Step 3 – 2012 Awardees

Budget period is anticipated to begin May 1, 2012 and must be spent by April 30, 2013. There will not be any no-cost extensions.
All final applicants will receive a detailed critique of their application

Unsuccessful applicants may resubmit their applications for the next round up to a total of two (2) times.  The RRC may deny the opportunity to resubmit an application if the reviewers determine the application does not meet the intent of the program.

Reporting requirements

Ignition Awards are an investment in translational research to improve human health. Meetings with ITHS representatives to assess the effective utilization of ITHS resources and required progress and results reporting are important aspects that aid in evaluating the success of this funding mechanism.

ITHS and WaNPRC each have specific requirements for reporting.

The ITHS requires the following reports and presentations:

  • Pre-award meeting with the DDAC to establish other ITHS resources that would benefit your program.
  • A brief semi-annual progress report to the ITHS Center for Scientific Review during the award period, and subsequent annual reports to track impact of the funding.
  • Annual report and presentation to DDAC.

The WaNPRC requires an annual report to be included with the grant report to sponsor.

Quarterly in-person meetings with an ITHS representative may be requested to track the progress of funded activities.

Publicity

The WaNPRC and the ITHS reserve the right to publicly disclose information about their granting activities. ITHS communications to the public may include lists of funded applications, the names of principal investigators and applicant institutions and departments, titles of proposed activities and reports about progress and outcomes. Please note that records produced at the University of Washington are subject to the Washington State Public Records Act, Chapter 42.56 RCW

Contact

For more information regarding the application process, please contact:

Preclinical Research Development Network  – ithsprdn@u.washington.edu

WaNPRC staff Ann Schmidt or Pat Jobe – PrimateITHS@wanprc.org